Plasmodium genomics: an approach for learning about and ending human malaria
JA Garrido-Cardenas, L González-Cerón… - Parasitology …, 2019 - Springer
Malaria causes high levels of morbidity and mortality in human beings worldwide. According
to the World Health Organization (WHO), about half a million people die of this disease each …
to the World Health Organization (WHO), about half a million people die of this disease each …
Systems biology of malaria explored with nonhuman primates
MR Galinski - Malaria journal, 2022 - Springer
Abstract “The Primate Malarias” book has been a uniquely important resource for multiple
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
generations of scientists, since its debut in 1971, and remains pertinent to the present day …
Identification of errors in draft genome assemblies at single-nucleotide resolution for quality assessment and improvement
Assembly of a high-quality genome is important for downstream comparative and functional
genomic studies. However, most tools for genome assembly assessment only give …
genomic studies. However, most tools for genome assembly assessment only give …
The Juicebox Assembly Tools module facilitates de novo assembly of mammalian genomes with chromosome-length scaffolds for under $1000
Hi-C contact maps are valuable for genome assembly (;;). Recently, we developed Juicebox,
a system for the visual exploration of Hi-C data, and 3D-DNA, an automated pipeline for …
a system for the visual exploration of Hi-C data, and 3D-DNA, an automated pipeline for …
A novel CRISPR-based malaria diagnostic capable of Plasmodium detection, species differentiation, and drug-resistance genotyping
CH Cunningham, CM Hennelly, JT Lin, R Ubalee… - …, 2021 - thelancet.com
Background CRISPR-based diagnostics are a new class of highly sensitive and specific
assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific …
assays with multiple applications in infectious disease diagnosis. SHERLOCK, or Specific …
Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages
The development of malaria parasites throughout their various life cycle stages is
coordinated by changes in gene expression. We previously showed that the three …
coordinated by changes in gene expression. We previously showed that the three …
Comparative 3D genome organization in apicomplexan parasites
The positioning of chromosomes in the nucleus of a eukaryotic cell is highly organized and
has a complex and dynamic relationship with gene expression. In the human malaria …
has a complex and dynamic relationship with gene expression. In the human malaria …
[HTML][HTML] Distinct amino acid and lipid perturbations characterize acute versus chronic malaria
Chronic malaria is a major public health problem and significant challenge for disease
eradication efforts. Despite its importance, the biological factors underpinning chronic …
eradication efforts. Despite its importance, the biological factors underpinning chronic …
Malaria genomics, vaccine development, and microbiome
Recent advances in malaria genetics and genomics have transformed many aspects of
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …
malaria research in areas of molecular evolution, epidemiology, transmission, host–parasite …
Third-generation sequencing revises the molecular karyotype for Toxoplasma gondii and identifies emerging copy number variants in sexual recombinants
Toxoplasma gondii is a useful model for intracellular parasitism given its ease of culture in
the laboratory and genomic resources. However, as for many other eukaryotes, the T. gondii …
the laboratory and genomic resources. However, as for many other eukaryotes, the T. gondii …