[HTML][HTML] Microfluidic devices for cell cultivation and proliferation

M Tehranirokh, AZ Kouzani, PS Francis, JR Kanwar - Biomicrofluidics, 2013 - pubs.aip.org
Microfluidic technology provides precise, controlled-environment, cost-effective, compact,
integrated, and high-throughput microsystems that are promising substitutes for …

Screening applications in drug discovery based on microfluidic technology

P Eribol, AK Uguz, KO Ulgen - Biomicrofluidics, 2016 - pubs.aip.org
Microfluidics has been the focus of interest for the last two decades for all the advantages
such as low chemical consumption, reduced analysis time, high throughput, better control of …

3D lung spheroid cultures for evaluation of photodynamic therapy (PDT) procedures in microfluidic Lab-on-a-Chip system

A Zuchowska, E Jastrzebska, M Chudy, A Dybko… - Analytica chimica …, 2017 - Elsevier
The purpose of this paper is to present a fully integrated microchip for the evaluation of PDT
procedures efficiency on 3D lung spheroid cultures. Human lung carcinoma A549 and non …

Advances in concentration gradient generation approaches in a microfluidic device for toxicity analysis

NME Valle, MP Nucci, AH Alves, LD Rodrigues… - Cells, 2022 - mdpi.com
This systematic review aimed to analyze the development and functionality of microfluidic
concentration gradient generators (CGGs) for toxicological evaluation of different biological …

The interplay of cells, polymers, and vascularization in three-dimensional lung models and their applications in COVID-19 research and therapy

TA Ahmed, B Eldaly, S Eldosuky, H Elkhenany… - Stem Cell Research & …, 2023 - Springer
Millions of people have been affected ever since the emergence of the corona virus disease
of 2019 (COVID-19) outbreak, leading to an urgent need for antiviral drug and vaccine …

Lab-on-a-chip systems for photodynamic therapy investigations

M Chudy, K Tokarska, E Jastrzębska, M Bułka… - Biosensors and …, 2018 - Elsevier
In recent years photodynamic therapy (PDT) has received widespread attention in cancer
treatment due to its smaller surgical trauma, better selectivity towards tumor cells, reduced …

Real-time detection and monitoring of the drug resistance of single myeloid leukemia cells by diffused total internal reflection

L Liang, YX Jin, XQ Zhu, FL Zhou, Y Yang - Lab on a Chip, 2018 - pubs.rsc.org
Real-time detection and monitoring of the drug resistance of single cells have important
significance in clinical diagnosis and therapy. Traditional methods operate a number of …

Impedimetric toxicity assay in microfluidics using free and liposome-encapsulated anticancer drugs

C Caviglia, K Zor, L Montini, V Tilli, S Canepa… - Analytical …, 2015 - ACS Publications
In this work, we have developed a microfluidic cytotoxicity assay for a cell culture and
detection platform, which enables both fluid handling and electrochemical/optical detection …

Adhesion of MRC‐5 and A549 cells on poly (dimethylsiloxane) surface modified by proteins

A Zuchowska, P Kwiatkowski, E Jastrzebska… - …, 2016 - Wiley Online Library
PDMS is a very popular material used for fabrication of Lab‐on‐a‐Chip systems for
biological applications. Although PDMS has numerous advantages, it is a highly …

Structural characterization of 5-fluorouracil & piperazine new solid forms and evaluation of their antitumor activity

M Muresan-Pop, G Chereches, G Borodi… - Journal of Molecular …, 2020 - Elsevier
Abstract A salt (FP–S) and two co-crystals (FP–C1 and FP-C2) of fluorouracil (FU) with
piperazine (PZ) were investigated in terms of bioavailability and their effect on endothelial …