A medicinal chemistry perspective on excitatory amino acid transporter 2 dysfunction in neurodegenerative diseases

IC Fontana, DG Souza, DO Souza, A Gee… - Journal of medicinal …, 2023 - ACS Publications
The excitatory amino acid transporter 2 (EAAT2) plays a key role in the clearance and
recycling of glutamate-the major excitatory neurotransmitter in the mammalian brain. EAAT2 …

Recent developments in carbon-11 chemistry and applications for first-in-human PET studies

A Pees, M Chassé, A Lindberg, N Vasdev - Molecules, 2023 - mdpi.com
Positron emission tomography (PET) is a molecular imaging technique that makes use of
radiolabelled molecules for in vivo evaluation. Carbon-11 is a frequently used radionuclide …

Carbon isotopic labelling of carboxylic acids enabled by organic photoredox-catalysed cyanation

Z Zhu, X Wu, GT Bida, H Deng, X Ma, S Qian, Z Wu… - Nature …, 2024 - nature.com
The application of molecular imaging has advanced personalized medicine and generated
a profound impact on patient care. Positron emission tomography and magnetic resonance …

Astrocyte signature in Alzheimer's disease continuum through a multi-PET tracer imaging perspective

IC Fontana, M Scarpa, ML Malarte, FM Rocha… - Cells, 2023 - mdpi.com
Reactive astrogliosis is an early event in the continuum of Alzheimer's disease (AD). Current
advances in positron emission tomography (PET) imaging provide ways of assessing …

Chelating positron-emitting radiometals for molecular imaging

Z Hong - Coordination Chemistry Reviews, 2025 - Elsevier
Positron emission tomography (PET) is a state of the art imaging modality, enabling the
sensitive molecular imaging in vivo. Central to PET imaging is the advancements of PET …

Advanced biological optical sensors for visualization and quantification of radionuclides

H Cai, F Jia, Q Cheng, R Ankri, J Cui, L Wang - TrAC Trends in Analytical …, 2024 - Elsevier
Radionuclides, a complex tool with immense potential, can propel modern medical imaging
forward while simultaneously posing grave risks. It is imperative to acknowledge the dual …

Reactive Palladium–Ligand Complexes for 11C-Carbonylation at Ambient Pressure: A Breakthrough in Carbon-11 Chemistry

K Dahl, A Lindberg, N Vasdev, M Schou - Pharmaceuticals, 2023 - mdpi.com
The Pd–Xantphos-mediated 11C-carbonylation protocol (also known as the “Xantphos-
method”), due to its simplistic and convenient nature, has facilitated researchers in meeting …

[HTML][HTML] Radiotracers for Molecular Imaging of Angiotensin-Converting Enzyme 2

W Xu, SA Langhans, DK Johnson, E Stauff… - International Journal of …, 2024 - mdpi.com
Angiotensin-converting enzymes (ACE) are well-known for their roles in both blood pressure
regulation via the renin-angiotensin system as well as functions in fertility, immunity …

30 years of [11C] methyl triflate

EM Jewett, K Någren, BH Mock, GL Watkins - Applied Radiation and …, 2023 - Elsevier
Some scientific discoveries are well known only to a core group of researchers working on
technical subjects. Nevertheless, they open new research directions, allow existing …

Highlight selection of radiochemistry and radiopharmacy developments by editorial board

J DaSilva, C Decristoforo, RH Mach, G Bormans… - EJNMMI radiopharmacy …, 2023 - Springer
Abstract Background The Editorial Board of EJNMMI Radiopharmacy and Chemistry
releases a biannual highlight commentary to update the readership on trends in the field of …