Acute graft-versus-host disease (GVHD) is a common immune complication that can occur
after allogeneic haematopoietic cell transplantation (alloHCT). Acute GVHD is a major …

Next-generation sequencing allows the analysis of genomes, including those representing
disease states. However, the causes of most disorders are multifactorial, and systems-level …

PURPOSE Severe (grade 3-4) acute graft-versus-host disease (AGVHD) is a major cause of
death after unrelated-donor (URD) hematopoietic cell transplant (HCT), resulting in …

Proteins in the circulatory system mirror an individual's physiology. In daily clinical practice,
protein levels are generally determined using single-protein immunoassays. High …

Objective This paper describes the University of Michigan's nine-year experience in
developing and using a full-text search engine designed to facilitate information retrieval (IR) …

Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD)
that lead to severe manifestations remains a challenge. The standardization provided by the …

For over 60 years, hematopoietic stem cell transplantation has been the major curative
therapy for several hematological and genetic disorders, but its efficacy is limited by the …

Background No plasma biomarkers are associated with the response of acute graft-versus-
host disease (GVHD) to therapy after allogeneic hematopoietic stem-cell transplantation …

Acute graft-versus-host disease (GVHD) is treated with systemic corticosteroid
immunosuppression. Clinical response after 1 week of therapy often guides further treatment …

Methods A PubMed search was conducted using the search terms “graft versus host
disease,”“acute GVHD,”“chronic GVHD,”“pathophysiology,”“diagnosis,” and “treatment.” …