Mechanism of drug‐induced gingival overgrowth revisited: a unifying hypothesis

RS Brown, PR Arany - Oral diseases, 2015 - Wiley Online Library
Drug‐induced gingival overgrowth (DIGO) is a disfiguring side effect of anti‐convulsants,
calcineurin inhibitors, and calcium channel blocking agents. A unifying hypothesis has been …

Cyclosporine‐induced gingival overgrowth

J Chojnacka‐Purpurowicz, E Wygonowska… - Dermatologic …, 2022 - Wiley Online Library
Drug‐induced gingival overgrowth (DIGO) is an undesirable effect resulting from the therapy
of one of the three groups of drugs: phenytoin, calcium channel blockers, and cyclosporine A …

Epithelial-to-mesenchymal transition, inflammation, subsequent collagen production, and reduced proteinase expression cooperatively contribute to cyclosporin-A …

M Imagawa, T Shinjo, K Sato, K Kawakami… - Frontiers in …, 2023 - frontiersin.org
Drug-induced gingival overgrowth (DIGO), induced by certain immunosuppressive drugs,
antihypertensive agents, and antiepileptic drugs, may contribute to the formation of deeper …

[HTML][HTML] Prevalence of Gingival Enlargement Induced by Antihypertensive Drugs

HA Ibrahim, AF Al Zubaidee - The International Tinnitus Journal, 2024 - tinnitusjournal.com
Introduction: Drug-Induced Gingival Overgrowth (DIGO) is a pathological growth of the
gingival tissue, which may occur as a side effect of certain drugs including some …

Drug-induced gingival overgrowth: a pilot study on the effect of diphenylhydantoin and gabapentin on human gingival fibroblasts

D Lauritano, G Moreo, L Limongelli… - International Journal of …, 2020 - mdpi.com
Introduction. The administration of several classes of drugs can lead to the onset of gingival
overgrowth: anticonvulsants, immunosuppressants, and calcium channel blockers. Among …

Targeting SRD5A1 and MMP-2/NLRP3/TGF-β1 axis alleviates the amlodipine-induced gingival hyperplasia in rats: Emerging role of saw palmetto and folic acid

MM El Tabaa, MM Aboud, A Anis, E Rashad… - Food and Chemical …, 2024 - Elsevier
Saw palmetto (SAW), the herbal drug used to treat prostatic hyperplasia, exerts its
antiproliferative effects by blocking steroid 5 alpha-reductase (SRD5A1) activity, that has …

Progress in the use of autologous regenerative platelet-based therapies in implant dentistry

E Anitua, M Troya, M Zalduendo… - Current …, 2016 - ingentaconnect.com
The field of medicine is rapidly moving towards the development of personalized treatments
and non-invasive tools to achieve a more predictable and optimal tissue regeneration. In this …

Increased and correlated expression of connective tissue growth factor and transforming growth factor beta 1 in surgically removed periodontal tissues with chronic …

TW Mize, KP Sundararaj, RS Leite… - Journal of Periodontal …, 2015 - Wiley Online Library
Background and Objective Both gingival tissue destruction and regeneration are associated
with chronic periodontitis, although the former overwhelms the latter. Studies have shown …

Calcium-channel-blocker-influenced gingival enlargement: A conundrum demystified

P Tonsekar, V Tonsekar - Oral, 2021 - mdpi.com
The aim of the article is to discuss the development of calcium channel blocker (CCB)
influenced gingival enlargement. Data and Sources: MEDLINE/PubMed, Scopus …

[HTML][HTML] Expression of epithelial–mesenchymal transition-associated proteins and proliferating cell nuclear antigen in dihydropyridine-induced gingival overgrowth …

PH Chen, YT Chuang, CF Huang, HK Lu - Journal of Dental Sciences, 2023 - Elsevier
Background/purpose The clinical features of dihydropyridine-induced gingival overgrowth
(DIGO), including extracellular matrix accumulation and cell hyperplasia, are regulated by …