Polyamines are essential for the proliferation, differentiation, and development of
eukaryotes. They include spermine, spermidine, and the diamine precursor putrescine, and …

Polycationic polyamines are present in nearly all living organisms and are essential for
mammalian cell growth and survival, and for development. These positively charged …

Cancer metabolic reprogramming is essential for maintaining cancer cell survival and rapid
replication. A common target of this metabolic reprogramming is one-carbon metabolism …

Guanidino acids such as taurocyamine, guanidinobutyrate, guanidinopropionate, and
guanidinoacetate have been detected in humans. However, except for guanidionacetate …

Lung adenocarcinoma (LUAD) is one of the leading causes of cancer-related death
worldwide. There is an urgent need to uncover the pathogenic mechanism to develop new …

Spermidine, a natural polyamine, exists in almost all human tissues, exhibiting broad
properties like anti-aging, autophagy induction, anti-inflammation, anti-oxidation, cell …

The essence of enzymes is to keep the homeostasis and balance of humans by catalyzing
metabolic responses and modulating cells. Suppression of an enzyme slows the progress of …

Elevated polyamine levels are required for tumor transformation and development; however,
expression patterns of polyamines and their diagnostic potential have not been investigated …

Purpose Several cancer subtypes (pancreatic, breast, liver, and colorectal) rapidly advance
to higher aggressive stages in diabetes. Though hyperglycemia has been considered as a …

The gut microbiota regulates multiple facets of host metabolism and immunity through the
production of signaling metabolites, such as polyamines which are small organic …