The blood-brain barrier (BBB) is involved in the pathogenesis of Alzheimer's disease (AD).
BBB is a highly selective semipermeable structural and chemical barrier which ensures a …

The blood–brain barrier (BBB) represents a key challenge in developing brain-penetrating
therapeutic molecules. BBB dysfunction is also associated with the onset and progression of …

The blood–brain barrier (BBB) plays a vital role in maintaining the specialized
microenvironment of the brain tissue. It facilitates communication while separating the …

Direct nose-to-brain delivery has been raised as a non-invasive powerful strategy to deliver
drugs to the brain bypassing the blood-brain barrier (BBB). This study aimed at preparing …

Alzheimer's disease (AD) is a progressive and degenerative disease producing the most
common type of dementia worldwide. The main pathogenetic hypothesis in recent decades …

A series of new coumarin/1, 2, 4-oxadiazole hybrids were synthesized and evaluated for
cholinesterase inhibitory and neuroprotective activities. Among them, enantiomers 5u and …

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
Huntington's disease are very harmful brain lesions. Due to the difficulty in obtaining …

A marine natural product, pulmonarin B (1), and a series of related tacrine hybrid analogues
were synthesized and evaluated as cholinesterase (ChE) inhibitors. The in vitro ChE assay …

Acetylcholinesterase (AChE) inhibition is a significant strategy for preventing Alzheimer's
disease (AD) and neurodegenerative diseases. In this study, a dereplication system was …

Despite continuation of some controversies, Alzheimer's disease (AD), the most common
cause of dementia nowadays, has been widely believed to derive mainly from excessive β …