As part of the neurovascular unit, the blood-brain barrier (BBB) is a unique, dynamic
regulatory boundary that limits and regulates the exchange of molecules, ions, and cells …

Recanalization therapy is increasingly used in the treatment of acute ischemic stroke.
However, in about one third of these patients, recanalization is followed by …

Nitric oxide (NO) is a key signalling molecule in the regulation of cerebral blood flow. This
review summarises current evidence regarding the role of NO in the regulation of cerebral …

This review covers the pathogenesis of ischemic stroke and future directions regarding
therapeutic options after injury. Ischemic stroke is a devastating disease process affecting …

The discovery that mammalian cells have the ability to synthesize the free radical nitric oxide
(NO) has stimulated an extraordinary impetus for scientific research in all the fields of …

This review concentrates on advances in nitric oxide synthase (NOS) structure, function and
inhibition made in the last seven years, during which time substantial advances have been …

The accumulation of unfolded proteins in the endoplasmic reticulum (ER) represents a
cellular stress induced by multiple stimuli and pathological conditions. These include …

Brain injury following transient or permanent focal cerebral ischaemia (stroke) develops from
a complex series of pathophysiological events that evolve in time and space. In this article …

Endoplasmic reticulum (ER) is the site of synthesis and folding of secretory proteins.
Perturbations of ER homeostasis affect protein folding and cause ER stress. ER can sense …

This review is directed at understanding how neuronal death occurs in two distinct insults,
global ischemia and focal ischemia. These are the two principal rodent models for human …