▪ Abstract Neurotransmitter release is mediated by exocytosis of synaptic vesicles at the
presynaptic active zone of nerve terminals. To support rapid and repeated rounds of release …

Nerve terminals are specific sites of action of a very large number of toxins produced by
many different organisms. The mechanism of action of three groups of presynaptic …

Tetanus and botulinum neurotoxins are produced by Clostridia and cause the neuroparalytic
syndromes of tetanus and botulism. Tetanus neurotoxin acts mainly at the CNS synapse …

Brain-derived neurotrophic factor (BDNF) promotes long-term potentiation (LTP) at
hippocampal CA1 synapses by a presynaptic enhancement of synaptic transmission during …

Synaptophysin (Syp) was the first synaptic vesicle (SV) protein to be cloned. Since its
discovery in 1985, it has been used by us and by many laboratories around the world as an …

Optogenetic techniques provide effective ways of manipulating the functions of selected
neurons with light. In the current study, we engineered an optogenetic technique that directly …

Abstract Synaptobrevin‐2 (Syb2) is a soluble N‐ethylmaleimide‐sensitive factor attachment
protein receptor (SNARE) that is essential for neurotransmitter release. It is the most …

Brain extracellular matrix (ECM) is organized in specific patterns assumed to mirror local
features of neuronal activity and synaptic plasticity. Aggrecan‐based perineuronal nets …

The activity‐dependent fusion, retrieval and recycling of synaptic vesicles is essential for the
maintenance of neurotransmission. Until relatively recently it was believed that most …

Eukaryotes have a remarkably well-conserved apparatus for the trafficking of proteins
between intracellular compartments and delivery to their target organelles. This apparatus …