Sensory perception and emotional disorders are disproportionally represented in men and
women and are thus thought to be modulated by different sex hormones in various …

Because of the problems associated with opioids, drug discovery efforts have been
employed to develop opioids with reduced side effects using approaches such as biased …

Accumulating evidence suggests that inflammation plays an important role in the
pathophysiology of the initiation and progression of cardiovascular and metabolic diseases …

GPR18 is a G-protein-coupled receptor that belongs to the orphan class A family. Even
though it shares low sequence homology with the cannabinoid receptors CB1R and CB2R …

Drug use poses a serious threat to health systems throughout the world and the number of
consumers rises relentlessly every year. The kynurenine pathway, main pathway of …

G protein-coupled receptors (GPCRs) make up the largest receptor superfamily, accounting
for 4% of protein-coding genes. Despite the prevalence of such transmembrane receptors, a …

Abstract Background Neutrophil extracellular traps (NETs) promote neuroinflammation and,
thus, central nervous system (CNS) disease progression. However, it remains unclear …

Bone cancer pain (BCP) is a pervasive clinical symptom which impairs the quality life. Long
noncoding RNAs (lncRNAs) are enriched in the central nervous system and play …

Background The activation of cannabinoid and cannabinoid‐related receptors by
endogenous, plant‐derived or synthetic cannabinoids may exert beneficial effects on pain …

G protein-coupled receptors (GPCRs) are a large family of transmembrane proteins that are
expressed in many organs and serve as important drug targets. A new subgroup, namely …