The transduction of mechanical stimuli produced by blood flow is an important regulator of
vascular development. The vitelline and umbilico-placental circulations are extraembryonic …

Early organogenesis represents a key step in animal development, during which pluripotent
cells diversify to initiate organ formation. Here, we sampled 300,000 single-cell …

During the early development of Placentalia, a distinctive projection emerges at the posterior
embryonic–extraembryonic interface of the conceptus; its fingerlike shape presages …

Human expanded potential stem cells (hEPSC) have been derived from human embryonic
stem cells and induced pluripotent stem cells. Here direct derivation of hEPSC from human …

Hypoblast/visceral endoderm assists in amniote nutrition, axial positioning and formation of
the gut. Here, we provide evidence, currently limited to humans and non-human primates …

In Placentalia, the fetus depends upon an organized vascular connection with its mother for
survival and development. Yet, this connection was, until recently, obscure. Here, we …

Highlights•Hypoblast/visceral endoderm of Placentalia may be hematopoietic.•Putative
blood cells have been observed in the hypoblast layer of the yolk sac.•Mouse allantois …

Primordial germ cells (PGCs), the precursors of the gametes, are now claimed to segregate
within the extra-embryonic tissues of three species of placental mammals. In this brief …

Signaling pathways regulate multiple aspects of vertebrate embryonic development.
Members of Transforming Growth Factor β (Tgfβ) superfamily in particular, are involved in …