Understanding the roles of compaction pressure and crystal hardness on powder tabletability through bonding area–Bonding strength interplay

L Shi, CC Sun - International Journal of Pharmaceutics, 2024 - Elsevier
Bonding area (BA) and bonding strength (BS) interplay dictates tensile strength of a tablet
and, hence, tabletability. Using a series of alkali halides with mechanical properties …

Simultaneously improving tabletability and solubility of diclofenac by cocrystallization with picolinamide

C Wu, Z Wang, X Han, X Yu, CC Sun, Z Zhou - International Journal of …, 2025 - Elsevier
Diclofenac (DIC) is a nonsteroidal anti-inflammatory drug with poor tabletability and water
solubility. In the present study, a new diclofenac-picolinamide cocrystal (DIC-PIC) was …

Direct compression tablet formulation of trimetazidine through systematic screening of oxalate salts

Y Ge, Z Yuan, M Zhang, Y Ming, X Huang… - International Journal of …, 2025 - Elsevier
Salt formation has been extensively used to modulate and improve the properties of active
pharmaceutical ingredients (API), such as solubility, stability and mechanical properties …