More than 10 years have passed since the naming of periostin derived from its expression
sites in the periosteum and periodontal ligament. Following this finding, we have …

Integrity of the extracellular matrix (ECM) is essential for maintaining the normal structure
and function of connective tissues. ECM is secreted locally by cells and organized into a …

Periostin is predominantly expressed in collagen‐rich fibrous connective tissues that are
subjected to constant mechanical stresses including: heart valves, tendons, perichondrium …

Loss of pulp due to caries and pulpitis leads to loss of teeth and reduced quality of life. Thus,
there is an unmet need for regeneration of pulp. A promising approach is stem cell therapy …

Intra-and intermolecular covalent cross-linking between collagen fibrils, catalyzed by lysyl
oxidase (LOX), determines the mechanical properties of connective tissues; however …

Extracellular matrix (ECM) underlies a complicated multicellular architecture that is
subjected to significant forces from mechanical environment. Although various components …

Periostin is a secretory protein with a multi-domain structure, comprising an amino-terminal
cysteine-rich EMI domain, four internal FAS 1 domains, and a carboxyl-terminal hydrophilic …

Periostin is a unique extracellular matrix protein, deposition of which is enhanced by
mechanical stress and the tissue repair process. Its significance in normal and neoplastic …

Objectives Mesenchymal stem cell (MSC)‐mediated periodontal tissue regeneration is
considered to be a promising method for periodontitis treatment. The molecular mechanism …

During tissue healing, the dynamic and temporal alterations required for effective repair
occur in the structure and composition of the extracellular matrix (ECM). Matricellular …