The breakthrough discoveries of leptin and adiponectin more than two decades ago led to a
widespread recognition of adipose tissue as an endocrine organ. Many more adipose tissue …

Adipose tissue is a central metabolic organ. Unlike other organs, adipose tissue is
compartmentalized into individual depots and distributed throughout the body. These …

Fibrosis in adipose tissue is a major driver of obesity-related metabolic dysregulation. It is
characterized by an overaccumulation of extracellular matrix (ECM) during unhealthy …

Biochemistry of Collagens, Laminins, and Elastin: Structure, Function and Biomarkers, Third
Edition provides current data on key structural proteins (collagens, laminins, and elastin) …

Background Endotrophin, a collagen type VI–derived peptide, mediates metabolic
dysregulation, inflammation, and fibrosis in animal models, but has not been studied in …

The remodeling of the extracellular matrix (ECM) by several protease families releases a
number of bioactive fragments, which regulate numerous biological processes such as …

Fibrosis is recognized as the major pathological change in adipose tissue during the
development of obesity. However, the detailed mechanisms governing the interactions …

Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …

Background: With an increasing prevalence of obesity and metabolic syndrome, exploring
the effects and delineating the mechanisms of possible therapeutic agents are of critical …

The globally increasing prevalence of obesity is associated with the development of
metabolic diseases such as type 2 diabetes, dyslipidemia, and fatty liver. Excess adipose …