Transforming growth factor β (TGF-β) is a secreted cytokine that regulates cell proliferation,
migration, and the differentiation of a plethora of different cell types. Consistent with these …

Metastasis is the major cause of death in patients with colorectal carcinoma (CRC). The
most common sites of metastasis are the liver and the peritoneum. Peritoneal …

Members of the miR-34 family are induced by the tumor suppressor p53 and are known to
inhibit epithelial-to-mesenchymal transition (EMT) and therefore presumably suppress the …

Tumor metastasis is a multi-step process by which tumor cells disseminate from their primary
site and form secondary tumors at a distant site. And metastasis is the major cause of death …

The microRNA (miRNA)-34a is a key regulator of tumor suppression. It controls the
expression of a plethora of target proteins involved in cell cycle, differentiation and …

MicroRNA miR-34a is recognized as a master regulator of tumor suppression. The strategy
of miR-34a replacement has been investigated in clinical trials as the first attempt of miRNA …

The miR-34a and miR-34b/c encoding genes represent direct targets of the p53 transcription
factor, and presumably mediate part of the tumor suppressive effects of p53. Here, we …

The tumor suppressor p53 is one of the most frequently mutated genes in human cancers.
MicroRNAs (miRNAs) are small non-protein coding RNAs that regulate gene expression on …

The mir-34 family was originally cloned and characterized in 2007 as a p53 target gene.
Almost immediately it became clear that its major role is as a master regulator of tumor …

Colorectal cancer (CRC) is one of the most commonly diagnosed malignancies with a high
incidence and mortality rate. An essential challenge in colorectal cancer management is to …