Abstract microRNAs (miRNAs) play a central role in the regulation of gene expression by
targeting specific mRNAs for degradation or translational repression. Each miRNA is post …

Small RNA molecules regulate eukaryotic gene expression during development and in
response to stresses including viral infection. Specialized ribonucleases and RNA-binding …

RNA-mediated gene silencing in human cells requires the accurate generation of∼ 22 nt
microRNAs (miRNAs) from double-stranded RNA substrates by the endonuclease Dicer …

Mosquitoes live under the endless threat of infections from different kinds of pathogens such
as bacteria, parasites, and viruses. The mosquito defends itself by employing both physical …

Nearly every cell in the human body contains a set of programmable gene-silencing proteins
named Argonaute. Argonaute proteins mediate gene regulation by small RNAs and thereby …

Homeostatic mechanisms regulate the abundance of several components in small-RNA
pathways. We used Drosophila and mammalian systems to demonstrate a conserved …

Background Many eukaryotic genomes encode cis-natural antisense transcripts (cis-NATs).
Sense and antisense transcripts may form double-stranded RNAs that are processed by the …

We have used genome editing to generate inactivating deletion mutations in all three copies
of the dicer (hdcr) gene present in the human cell line 293T. As previously shown in murine …

Abstract The Asian citrus psyllid (Diaphorina citri Kuwayama) is the insect vector of the
bacterium Candidatus Liberibacter asiaticus (CLas), the pathogen associated with citrus …

The tomato russet mite, Aculops lycopersici, is among the smallest animals on earth. It is a
worldwide pest on tomato and can potently suppress the host's natural resistance. We …