Epithelial cells require apical–basal plasma membrane polarity to carry out crucial vectorial
transport functions and cytoplasmic polarity to generate different cell progenies for tissue …

Glycosylphosphatidylinositols (GPIs) act as membrane anchors of many eukaryotic cell
surface proteins. GPIs in various organisms have a common backbone consisting of …

Hepatocytes, like other epithelia, are situated at the interface between the organism's
exterior and the underlying internal milieu and organize the vectorial exchange of …

Positioned at the C-terminus of many eukaryotic proteins, the glycosylphosphatidylinositol
(GPI) anchor is a posttranslational modification that anchors the modified protein in the outer …

The trans-Golgi network (TGN) is an important cargo sorting station within the cell where
newly synthesized proteins are packaged into distinct transport carriers that are targeted to …

Experiments using mammalian epithelial cell lines have elucidated biosynthetic and
recycling pathways for apical and basolateral plasma-membrane proteins, and have …

The composition and identity of cell organelles are dictated by the flux of lipids and proteins
that they receive and lose through cytosolic exchange and membrane trafficking. The trans …

Advanced single-molecule fluorescent imaging was applied to study the dynamic
organization of raft-associated glycosylphosphatidylinositol-anchored proteins (GPI-APs) in …

In the early days of epithelial cell biology, researchers working with kidney and/or intestinal
epithelial cell lines and with hepatocytes described the biosynthetic and recycling routes …

Polarized intracellular trafficking in epithelia is critical in development, immunity, and
physiology to deliver morphogens, defensins, or ion pumps to the appropriate membrane …