Background: Exercise is medicine. Multiple studies on the effects and mechanisms of
exercise in treating depression among teenagers and adolescents have been widely …

Objective: Early-life adversity (ELA) is one of the strongest predictors of childhood
depression that may be exacerbated by a genetic predisposition to develop depression. We …

During the peripartum period, women are at an increased risk to develop perinatal distress,
presenting as symptoms of depression and/or anxiety. Yet, due to practical and ethical …

Objectives The aim of this study was to repurpose a drug for the treatment of bipolar
depression. Methods A gene expression signature representing the overall transcriptomic …

The Ndufs4 knockout (KO) mouse is a validated and robust preclinical model of
mitochondrial diseases (specifically Leigh syndrome), that displays a narrow window of …

Exercise is known to promote efficient function of stress circuitry. The developing brain is
malleable and thus exercise during adolescence could potentially exert lasting beneficial …

Objective: We aimed to answer the questions of whether early-life (perinatal and/or juvenile)
exercise can induce antidepressant-like effects in a validated rodent model of depression …

Objective: To investigate the long-term effects of juvenile sub-chronic sildenafil (SIL)
treatment on the depressive-like behaviour and hippocampal brain-derived neurotrophic …

The brain and its associated disorders as a field of study are extremely complex, even more
so when research strives to create models that mimic human psychiatric conditions. Given …

Aktualnym i wiodącym problemem zdrowotnym wielu krajów na całym świecie jest
pandemia COVID-19. Do 25. lipca 2020 r. w różnych regionach świata odnotowano łącznie …