The mechanisms of catalysis and ligand binding for the SARS-CoV-2 NSP3 macrodomain from neutron and x-ray diffraction at room temperature
GJ Correy, DW Kneller, G Phillips, S Pant, S Russi… - Science …, 2022 - science.org
The nonstructural protein 3 (NSP3) macrodomain of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2)(Mac1) removes adenosine diphosphate (ADP) ribosylation …
coronavirus 2 (SARS-CoV-2)(Mac1) removes adenosine diphosphate (ADP) ribosylation …
Insights into mechanisms of ubiquitin ADP-ribosylation reversal
Z Zhang, C Das - Biochemical Society Transactions, 2024 - portlandpress.com
Ubiquitination and ADP-ribosylation are two types of post-translational modification (PTM)
involved in regulating various cellular activities. In a striking example of direct interplay …
involved in regulating various cellular activities. In a striking example of direct interplay …
Mutation of a highly conserved isoleucine residue in loop 2 of several β-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental for …
CM Kerr, JJ Pfannenstiel, YM Alhammad… - Journal of …, 2024 - journals.asm.org
All coronaviruses (CoVs) encode for a conserved macrodomain (Mac1) located in non-
structural protein 3. Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes mono-ADP …
structural protein 3. Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes mono-ADP …
Metabolic Activation of PARP as a SARS-CoV-2 Therapeutic Target—Is It a Bait for the Virus or the Best Deal We Could Ever Make with the Virus? Is AMBICA the …
P Puthanveetil - Biomolecules, 2023 - mdpi.com
The COVID-19 pandemic has had a great impact on global health and is an economic
burden. Even with vaccines and anti-viral medications we are still scrambling to get a …
burden. Even with vaccines and anti-viral medications we are still scrambling to get a …
Reversible modification of mitochondrial ADP/ATP translocases by paired Legionella effector proteins
T Kubori, J Lee, H Kim, K Yamazaki… - Proceedings of the …, 2022 - National Acad Sciences
Adenosine diphosphate (ADP) ribosylation is a reversible posttranslational modification
involved in the regulation of numerous cellular processes. Prototype ADP …
involved in the regulation of numerous cellular processes. Prototype ADP …
Structure prediction and analysis of hepatitis E virus non-structural proteins from the replication and transcription machinery by AlphaFold2
Hepatitis E virus (HEV) is a major cause of acute viral hepatitis in humans globally.
Considered for a long while a public health issue only in developing countries, the HEV …
Considered for a long while a public health issue only in developing countries, the HEV …
[HTML][HTML] Mutation of highly conserved residues in loop 2 of the coronavirus macrodomain demonstrates that enhanced ADP-ribose binding is detrimental to infection
CM Kerr, JJ Pfannenstiel, YM Alhammad, A Roy… - bioRxiv, 2024 - ncbi.nlm.nih.gov
All coronaviruses (CoVs) encode for a conserved macrodomain (Mac1) located in
nonstructural protein 3 (nsp3). Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes …
nonstructural protein 3 (nsp3). Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes …
Identification of a series of pyrrolo-pyrimidine based SARS-CoV-2 Mac1 inhibitors that repress coronavirus replication
JJ Pfannenstiel, MTH Duong, D Cluff, L Sherrill… - bioRxiv, 2024 - biorxiv.org
Coronaviruses (CoVs) can emerge from zoonotic sources and cause severe diseases in
humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes …
humans and animals. All CoVs encode for a macrodomain (Mac1) that binds to and removes …
Designing a Light-Induced Glycosylation Reaction for Poststage Synthesis of ADP-2 ″-Deoxyribosyl Derivatives
J Shen, G Zhu, Y You, B Huo, F Dai, H Wang… - Organic …, 2023 - ACS Publications
Modifications on the hydroxyl groups of ADP-ribosyl units can provide valuable tools for
investigating ADP-ribosylation-related molecular interactions, but the chemical syntheses of …
investigating ADP-ribosylation-related molecular interactions, but the chemical syntheses of …