Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

Glucagon-Like Peptides | Endocrine Reviews | Oxford Academic Skip to Main Content
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Glucagon, a hormone secreted from the α-cells of the endocrine pancreas, is critical for
blood glucose homeostasis. It is the major counterpart to insulin and is released during …

Extracellular matrix (ECM) molecules are responsible for structural and biochemical support,
as well as for regulation of molecular signalling and tissue repair in many organ structures …

The discovery, characterization, and clinical development of glucagon-like-peptide-1 (GLP-
1) spans more than 30 years and includes contributions from multiple investigators, science …

The proglucagon gene (glu) encodes glucagon, expressed in pancreatic islets, and the
insulinotropic hormone GLP-1, expressed in the intestines. These two hormones exert …

One of the oldest problems in evolutionary biology remains largely unsolved. Which
mutations generate evolutionarily relevant phenotypic variation? What kinds of molecular …

While insulin has long been known to modulate intracellular metabolism by altering the
activity or intracellular location of various enzymes, it is only in the past 10 years that the …

The pancreatic β cell is the major source of circulating insulin in adult mammals. In the
multistep process of insulin synthesis it is initiation of transcription that restricts insulin …

The transcription factor Pdx1 is expressed in the pancreatic β-cell, where it is believed to
regulate several β-cell-specific genes. Whereas binding by Pdx1 to elements of β-cell genes …