TTN mutations predict a poor prognosis in patients with thyroid cancer

X Han, J Chen, J Wang, J Xu, Y Liu - Bioscience Reports, 2022 - portlandpress.com
Objective: We aimed to investigate the relationship between titin (TTN) gene mutations and
thyroid cancer (THCA) and to explore the feasibility of the TTN gene as a potential …

[HTML][HTML] Genetic predisposition to ocular surface disorders and opportunities for gene-based therapies

D Roshandel, F Semnani, AR Damavandi, A Masoudi… - The Ocular Surface, 2023 - Elsevier
The ocular surface, comprised of the corneal and conjunctival epithelium, innervation
system, immune components, and tear-film apparatus, plays a key role in ocular integrity as …

Ocular Surface Squamous Neoplasia: Update on Genetics, Epigenetics and Opportunities for Targeted Therapy

NE Kounatidou, E Vitkos, S Palioura - The Ocular Surface, 2024 - Elsevier
Purpose The purpose of this review is to explore the molecular foundations of ocular surface
squamous neoplasia (OSSN), focusing on the genetic and epigenetic aspects. While current …

Intrinsic disorder in BAP1 and its association with uveal melanoma

MB Djulbegovic, DJ Taylor, VN Uversky, A Galor… - Genes, 2022 - mdpi.com
Background: Specific subvariants of uveal melanoma (UM) are associated with increased
rates of metastasis compared to other subvariants. BRCA1 (BReast CAncer gene 1) …

Intrinsic disorder may drive the interaction of PROS1 and MERTK in uveal melanoma

M Djulbegovic, DJT Gonzalez, M Antonietti… - International journal of …, 2023 - Elsevier
Background Class 2 uveal melanomas are associated with the inactivation of the BRCA1
((breast cancer type 1 susceptibility protein)-associated protein 1 (BAP1)) gene. Inactivation …

5-Fluorouracil and Anti-EGFR antibody scaffold chitosan-stabilized Pickering emulsion: Formulations, physical characterization, in-vitro studies in NCL-H226 cells …

S Bhattacharya, P Shinde, A Page, S Sharma - International Journal of …, 2023 - Elsevier
This research seeks to optimize a chitosan-stabilized Pickering emulsion (PE) containing 5-
fluorouracil (5-FU) as a potential Squamous Cell Carcinoma therapy. The 5-Fluorouracil was …

Comprehensive analysis of purine-metabolism-related gene signature for predicting ovarian cancer prognosis, immune landscape, and potential treatment options

J Liu, X Zhang, H Wang, X Zuo, L Hong - Journal of Personalized …, 2023 - mdpi.com
Purine metabolism is an important branch of metabolic reprogramming and has received
increasing attention in cancer research. Ovarian cancer is an extremely dangerous …

Titin as a potential novel therapeutic target in colorectal cancer

H Wei, K Ren, Q Zhang, Y Jin, B Cao… - Journal of Cellular …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is identified as a primary cause of death around the world. The
current chemotherapies are not cost‐effective. Therefore, finding novel potential therapeutic …

A Computational Approach to Characterize the Protein S-Mer Tyrosine Kinase (PROS1-MERTK) Protein-Protein Interaction Dynamics

MB Djulbegovic, DJT Gonzalez, L Laratelli… - Cell biochemistry and …, 2024 - Springer
Protein S (PROS1) has recently been identified as a ligand for the TAM receptor MERTK,
influencing immune response and cell survival. The PROS1–MERTK interaction plays a role …

Comparative Analysis of the Intrinsic Disorder Within the Layers of the Human Cornea

MB Djulbegovic, M Antonietti, DJT Gonzalez, R Mattes… - Cornea, 2025 - journals.lww.com
Purpose: The human cornea is essential for vision, providing structural integrity and
refractive power to the eye. Recent advancements have deepened our understanding of the …