NMR spectroscopy for metabolomics research

AH Emwas, R Roy, RT McKay, L Tenori, E Saccenti… - Metabolites, 2019 - mdpi.com
Over the past two decades, nuclear magnetic resonance (NMR) has emerged as one of the
three principal analytical techniques used in metabolomics (the other two being gas …

Recent advances and perspectives of metabolomics-based investigations in Parkinson's disease

Y Shao, W Le - Molecular neurodegeneration, 2019 - Springer
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease of the
central nervous system (CNS), which affects mostly older adults. In recent years, the …

The strengths and weaknesses of NMR spectroscopy and mass spectrometry with particular focus on metabolomics research

AHM Emwas - Metabonomics: Methods and protocols, 2015 - Springer
Mass spectrometry (MS) and nuclear magnetic resonance (NMR) have evolved as the most
common techniques in metabolomics studies, and each brings its own advantages and …

[HTML][HTML] Pure shift NMR

K Zangger - Progress in nuclear magnetic resonance spectroscopy, 2015 - Elsevier
Although scalar-coupling provides important structural information, the resulting signal
splittings significantly reduce the resolution of NMR spectra. Limited resolution is a particular …

Environmental metabolomics: an emerging approach to study organism responses to environmental stressors

BP Lankadurai, EG Nagato… - Environmental …, 2013 - cdnsciencepub.com
Metabolomics is the analysis of endogenous and exogenous low molecular mass
metabolites within a cell, tissue, or biofluid of an organism in response to an external …

NMR spectroscopy for metabolomics and metabolic profiling

CK Larive, GA Barding Jr, MM Dinges - Analytical chemistry, 2015 - ACS Publications
Applications of NMR for metabolomics and metabolic profiling continue to grow rapidly as
does the refinement of methods for the measurement, analysis, and interpretation of …

NMR-based metabolomics in human disease diagnosis: applications, limitations, and recommendations

AHM Emwas, RM Salek, JL Griffin, J Merzaban - Metabolomics, 2013 - Springer
Metabolomics is a dynamic and emerging research field, similar to proteomics,
transcriptomics and genomics in affording global understanding of biological systems. It is …

Standardizing the experimental conditions for using urine in NMR-based metabolomic studies with a particular focus on diagnostic studies: a review

AH Emwas, C Luchinat, P Turano, L Tenori, R Roy… - Metabolomics, 2015 - Springer
The metabolic composition of human biofluids can provide important diagnostic and
prognostic information. Among the biofluids most commonly analyzed in metabolomic …

Can NMR solve some significant challenges in metabolomics?

GAN Gowda, D Raftery - Journal of Magnetic Resonance, 2015 - Elsevier
The field of metabolomics continues to witness rapid growth driven by fundamental studies,
methods development, and applications in a number of disciplines that include biomedical …

Recommended strategies for spectral processing and post-processing of 1D 1H-NMR data of biofluids with a particular focus on urine

AH Emwas, E Saccenti, X Gao, RT McKay… - Metabolomics, 2018 - Springer
Abstract 1 H NMR spectra from urine can yield information-rich data sets that offer important
insights into many biological and biochemical phenomena. However, the quality and utility …