Helping B cells and antibody responses is a major function of CD4+ T cells. It has been 10
years since the publication of Bcl6 as the lineage-defining transcription factor for T follicular …

The identification of CD4+ T cells localizing to B cell follicles has revolutionized the
knowledge of how humoral immunity is generated. Follicular helper T (TFH) cells support …

COVID-19 exhibits extensive patient-to-patient heterogeneity. To link immune response
variation to disease severity and outcome over time, we longitudinally assessed circulating …

Single-cell sequencing technologies can be used to detect the genome, transcriptome and
other multi-omics of single cells. They can show the differences and evolutionary …

CD4+ follicular helper T (Tfh) cells play a vital role in providing help for B cells undergoing
selection and differentiation into activated antibody-secreting cells in mammalian germinal …

CD4+ T cell-derived interleukin 21 (IL-21) sustains CD8+ T cell responses during chronic
viral infection, but the helper subset that confers this protection remains unclear. Here, we …

T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in
secondary lymphoid tissues.'Tfh-like'populations not expressing the canonical Tfh cell …

As a hallmark of autoimmune rheumatic diseases, autoantibodies have been used in
diagnosis for decades. However, the immunological mechanism underlying their generation …

Aging results in profound immune dysfunction, resulting in the decline of vaccine
responsiveness previously attributed to irreversible defects in the immune system. In …

Viral infection is usually studied at the population level by averaging over millions of cells.
However, infection at the single-cell level is highly heterogeneous, with most infected cells …