TAAR agonists

Z Xu, Q Li - Cellular and molecular neurobiology, 2020 - Springer
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors
(GPCRs) that are evolutionarily conserved in vertebrates. The first discovered TAAR1 is …

Olfactory signaling via trace amine-associated receptors

A Dewan - Cell and tissue research, 2021 - Springer
Trace amine-associated receptors (TAARs) are a family of G protein-coupled receptors that
function as odorant receptors in the main olfactory system of vertebrates. TAARs are …

Molecular recognition of an odorant by the murine trace amine-associated receptor TAAR7f

A Gusach, Y Lee, AN Khoshgrudi, E Mukhaleva… - Nature …, 2024 - nature.com
There are two main families of G protein-coupled receptors that detect odours in humans,
the odorant receptors (ORs) and the trace amine-associated receptors (TAARs). Their amino …

From odor to oncology: non-canonical odorant receptors in cancer

SJ Park, PL Greer, N Lee - Oncogene, 2024 - nature.com
Odorant receptors, traditionally associated with olfaction as chemoreceptors, have been
increasingly recognized for their presence and diverse functions in various non-nasal …

IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Rodent reproductive behavior among males and females after exposure to …

JR Maxon, MM Mahoney - Reproduction, 2024 - rep.bioscientifica.com
In brief The rodent reproductive behavioral control column of the hypothalamus and the
hypothalamic-pituitary-gonadal (HPG) axis are critical systems that regulate copulatory …

Neural and hormonal basis of opposite-sex preference by chemosensory signals

Y Kondo, H Hayashi - International Journal of Molecular Sciences, 2021 - mdpi.com
In mammalian reproduction, sexually active males seek female conspecifics, while estrous
females try to approach males. This sex-specific response tendency is called sexual …

Pheromones that correlate with reproductive success in competitive conditions

KC Luzynski, D Nicolakis, MA Marconi, SM Zala… - Scientific Reports, 2021 - nature.com
The major urinary proteins (MUPs) of house mice (Mus musculus) bind and stabilize the
release of pheromones and other volatile organic compounds (VOCs) from urinary scent …

Genetic deletion of trace-amine associated receptor 9 (TAAR9) in rats leads to decreased blood cholesterol levels

RZ Murtazina, IS Zhukov, OM Korenkova… - International Journal of …, 2021 - mdpi.com
In the last two decades, interest has grown significantly in the investigation of the role of
trace amines and their receptors in mammalian physiology and pathology. Trace amine …

Coordination of two enhancers drives expression of olfactory trace amine-associated receptors

A Fei, W Wu, L Tan, C Tang, Z Xu, X Huo, H Bao… - Nature …, 2021 - nature.com
Olfactory sensory neurons (OSNs) are functionally defined by their expression of a unique
odorant receptor (OR). Mechanisms underlying singular OR expression are well studied …

The best smellers make the best choosers: mate choice is affected by female chemosensory receptor gene diversity in a mammal

PSC Santos, M Mezger, M Kolar… - … of the Royal …, 2018 - royalsocietypublishing.org
The products of the genes of the major histocompatibility complex (MHC) are known to be
drivers of pathogen resistance and sexual selection enhancing offspring genetic diversity …