Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Insufficient development of new antibiotics and the rising resistance of bacteria to those that
we have are putting the world at risk of losing the most widely curative class of medicines …

Abstract Hansen's disease (HD), or leprosy, continues to be endemic in many parts of the
world. Although multidrug therapy (MDT) is successful in curing a large number of patients …

Objectives To evaluate the accuracy of the CapitalBio Mycobacterium real-time polymerase
chain reaction (RT-PCR) detection test for pulmonary Mycobacterium tuberculosis (MTB) …

Herein we report the screening of a small library of aurones and their isosteric counterparts,
azaaurones and N‐acetylazaaurones, against Mycobacterium tuberculosis. Aurones were …

While target-based drug design has proved successful in several therapeutic areas, this
approach has not yet provided compelling outcomes in the field of antibacterial agents. This …

The emergence of drug-resistant strains of Mycobacterium tuberculosis (Mtb) impedes the
End TB Strategy by the World Health Organization aiming for zero deaths, disease, and …

Introduction Drug discovery in academia and industry poses contrasting challenges. While
academia focuses on producing new knowledge, industry is keen on product development …

Tuberculosis (TB) and leprosy are mycobacterial infections caused by Mycobacterium
tuberculosis and Mycobacterium leprae respectively. These diseases continue to be …

Due to their non-specific diagnostic patterns of ocular infection, differential diagnosis
between Mycobacterium (M.) chimaera and tuberculosis can be challenging. In both …