Nonalcoholic fatty liver disease (NAFLD) is a broad-spectrum disease, ranging from simple
hepatic steatosis to nonalcoholic steatohepatitis, which can progress to cirrhosis and liver …

Background The bone derived protein osteocalcin (OC), in its undercarboxylated (ucOC)
form, has a beneficial effect on energy metabolism and may be a future therapeutic target for …

Quercetin, a flavonoid found in natural medicines, has shown a role in disease prevention
and health promotion. Moreover, because of its recently identified contribution in regulating …

Many physiological osteocalcin-regulated functions are affected in adult offspring of mothers
experiencing unhealthy pregnancy. Furthermore, osteocalcin signaling during gestation …

Bone biology has long been driven by the question as to what molecules affect cell
differentiation or the functions of bone. Exploring this issue has been an extraordinarily …

A new schema proposes that the bone-derived osteocalcin (Ocn) peptide hormone activates
the G-protein–coupled receptor GPRC6A to directly regulate glucose and fat metabolism in …

The G protein–coupled receptor GPRC6A regulates various physiological processes in
response to its interaction with multiple ligands, such as extracellular basic amino acids …

Apart from basic roles such as supporting the body, protecting internal organs, and storing
calcium, the skeletal system also performs hormonal functions. In recent years, several …

Arginine (Arg) is one of the metabolically versatile essential amino acids. Dietary
supplementation with Arg has been shown to stimulate the secretion of insulin-like growth …

Bone is a dynamic tissue reshaped by constant bone formation and bone resorption to
maintain its function. The skeletal system accounts for approximately 70% of the total volume …