Absorption, distribution, metabolism and excretion (ADME) studies represent a fundamental
step in the early stages of drug discovery. In particular, the absorption of orally administered …

The permeability of biological membranes is one of the most important determinants of the
pharmacokinetic processes of a drug. Although it is often accepted that many drug …

Transporters in proximal renal tubules contribute to the disposition of numerous drugs.
Furthermore, the molecular mechanisms of tubular secretion have been progressively …

The amphetamine derivative (±)-3, 4-methylenedioxymethamphetamine (MDMA, ecstasy) is
a popular recreational drug among young people, particularly those involved in the dance …

Background: The Caco-2 monolayer has been used extensively for the high-throughput
screening of drug permeability and identification of substrates, inhibitors, and inducers of …

P-glycoprotein (Pgp) affects the absorption, distribution, and clearance of a variety of
compounds. Thus, identification of compounds that are Pgp substrates can aid drug …

The objectives of this study were (1) to investigate the transporter inhibition activity of three
nonionic surfactants on P-glycoprotein, the human intestinal peptide transporter, and the …

Drug transporters are expressed in many tissues such as the intestine, liver, kidney, and
brain, and play key roles in drug absorption, distribution, and excretion. The information on …

Thirty-one structurally diverse marketed central nervous system (CNS)-active drugs, one
active metabolite, and seven non-CNS-active compounds were tested in three P …

An accurate means of predicting blood–brain barrier (BBB) penetration and blood–brain
partitioning of NCEs (new chemical entities) would fulfill a major need in pharmaceutical …