Initially part of the field of artificial intelligence, machine learning (ML) has become a
booming research area since branching out into its own field in the 1990s. After three …

This review summarizes current advances in the role of transcriptional stochasticity in HIV-1
latency, which were possible in a large part due to the development of single-cell …

A major pharmacological assumption is that lowering disease-promoting protein levels is
generally beneficial. For example, inhibiting metastasis activator BACH1 is proposed to …

Despite effective antiretroviral therapy, HIV-1 persistence in the latent reservoir remains the
major barrier to cure. Current strategies for HIV-1 eradication require either inducing HIV-1 …

The existence of latent cellular reservoirs is recognized as the major barrier to an HIV cure.
Reactivating and eliminating “shock and kill” or permanently silencing “block and lock” the …

HIV latency regulation in monocytes and macrophages can vary according to signals
directing differentiation, polarization, and function. To investigate these processes, we …

HIV-1 latency remains a barrier to a functional cure because of the ability of virtually silent
yet inducible proviruses within reservoir cells to transcriptionally reactivate upon cell …

Human immunodeficiency virus type 1 (HIV-1) causes a major burden on global health, and
eradication of latent virus infection is one of the biggest challenges in the field. The circadian …

ABSTRACT HIV-1 can integrate viral DNA into host cell chromosomes and establish a long-
term stable latent viral reservoir, a major obstacle in curing HIV-1 infection. The reactivation …

The persistence of latent, replication-competent HIV-1 proviruses in resting CD4+ T cells,
and other cellular reservoirs, represents a major barrier to a cure. This reservoir is …