Natural killer (NK) cells contribute to the first line of defense against viruses and to the
control of tumor growth and metastasis spread. The discovery of HLA class I specific …

The functional capacities of natural killer (NK) cells differ within and between individuals,
reflecting considerable genetic variation.'Licensing/arming','disarming', and 'tuning'are …

Inhibitory signaling during natural killer (NK) cell education translates into increased
responsiveness to activation; however, the intracellular mechanism for functional tuning by …

In all human cells, human leukocyte antigen (HLA) class I glycoproteins assemble with a
peptide and take it to the cell surface for surveillance by lymphocytes. These include natural …

Highlights•NK cell education is endowed by independently-segregating polygenic KIR and
HLA which, combined, enable diverse effector functions.•Education counterbalances each …

Purpose Disease relapse remains a major challenge to successful outcomes in patients who
undergo allogeneic hematopoietic cell transplantation (HCT). Donor natural killer (NK) cell …

In this brief review and perspective, we address the question of whether the immune
responses that bring about immune control of acute HIV infection are the same as, or distinct …

Major histocompatibility complex class I (MHC-I) molecules play a crucial role in immunity by
capturing peptides for presentation to T cells and natural killer (NK) cells. The peptide …

Interactions between human leukocyte antigen (HLA) molecules on target cells and the
inhibitory killer cell immunoglobulin-like receptors (KIRs) and heterodimeric inhibitory …

Natural killer (NK) cells represent a critical defense against viral infections and cancers. NK
cells require integration of activating and inhibitory NK cell receptors to detect target cells …