Complex protein networks are involved in nearly all cellular processes. To uncover these
vast networks of protein interactions, various high-throughput screening technologies have …

Over the past decade, bimolecular fluorescence complementation (BiFC) has emerged as a
key technique to visualize protein-protein interactions in a variety of model organisms. The …

The yeast two-hybrid system pioneered the field of in vivo protein-protein interaction
methods and undisputedly gave rise to a palette of ingenious techniques that are constantly …

Many proteins can be split into fragments that spontaneously reassemble, without covalent
linkage, into a functional protein. For split green fluorescent proteins (GFPs), fragment …

Protein-protein interactions (PPIs) play crucial roles in various biological processes. Among
biochemical, genetic, and imaging approaches that have been used for the study of PPIs …

Imaging localization and dynamics of individual interacting protein pairs is essential but
often difficult due to the fluorescent background from other paired and non-paired …

Studies of protein-protein interactions deep in organs and in whole mammals have been
hindered by a lack of genetically encoded fluorescent probes in near-infrared region for …

Bimolecular fluorescence complementation (BiFC) has been widely used to visualize protein-
protein interactions (PPIs) in cells. Until now, however, the resolution of BiFC has been …

Background Protein interactions control the regulatory networks underlying developmental
processes. The understanding of developmental complexity will, therefore, require the …

It has become increasingly clear that protein-protein interactions (PPIs) are
compartmentalized in nanoscale domains that define the biochemical architecture of the …