G-protein-coupled receptors (GPCRs), which constitute the largest family of cell surface
receptors, were originally thought to function as monomers, but are now recognized as …

Chemokine receptors are critical regulators of cell migration in the context of immune
surveillance, inflammation, and development. The G protein–coupled chemokine receptor …

Any aspect of cell activity is regulated by extracellular signals that are recognized, decoded,
and transduced inside the cell via different classes of plasma membrane receptors. 1À3 G …

Toll-like receptors (TLRs) act as the first line of defense against bacterial and viral
pathogens by initiating critical defense signals upon dimer activation. The contribution of the …

Membrane proteins perform diverse functions in living organisms such as transporters,
receptors and channels. The functions of membrane proteins have been investigated with …

The functioning of GPCRs is classically described by the ternary complex model as the
interplay of three basic components: a receptor, an agonist, and a G protein. According to …

As part of the innate immune system, the Toll-like receptors (TLRs) represent key players in
the first line of defense against invading foreign pathogens, and are also major targets for …

Genes encoding membrane proteins have been estimated to comprise as much as 30% of
the human genome. Among these membrane, proteins are a large number of signaling …

For years, conventional drug design at G-protein coupled receptors (GPCRs) has mainly
focused on the inhibition of a single receptor at a usually well-defined ligand-binding site …

Anibamine, a novel pyridine quaternary alkaloid recently isolated from Aniba sp., has been
found to effectively bind to the chemokine receptor CCR5 with an IC50 at 1 μM in …