The Notch signaling pathway is an architecturally simple signaling mechanism, well known
for its role in cell fate regulation during organ development and in tissue homeostasis. In …

Metastasis is the overwhelming driver of cancer mortality, accounting for the majority of
cancer deaths. Many patients present with metastatic relapse years after eradication of the …

Notch signaling is involved in cell fate determination and deregulated in human solid
tumors. Hypoxia is an important feature in many solid tumors, which activates hypoxia …

The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

Aim Immunotherapy for glioblastoma multiforme (GBM) is limited because of a strongly
immunosuppressive tumor microenvironment (TME). Remodeling the immune TME is an …

Dormancy occurs when cells preserve viability but stop proliferating, which is considered an
important cause of tumor relapse, which may occur many years after clinical remission …

Women that present to the clinic with established breast cancer metastases have limited
treatment options. Yet, the majority of preclinical studies are actually not directed at …

Notch signaling, renowned for its role in regulating cell fate, organ development, and tissue
homeostasis across metazoans, is highly conserved throughout evolution. The Notch …

Background Lactate metabolism is critically involved in the tumor microenvironment (TME),
as well as cancer progression. It is important to note, however, that lactate metabolism …

Simple Summary Breast cancer cells travel via the bloodstream to the bone before the
cancer is detectable in the breast. These disseminated cells are resistant to adjuvant …