Therapeutic cancer vaccines have undergone a resurgence in the past decade. A better
understanding of the breadth of tumour-associated antigens, the native immune response …

Osteosarcoma, with poor survival after metastasis, is considered the most common primary
bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival …

Tumor-associated macrophages are an abundant cell type in the tumor microenvironment.
These macrophages serve as a promising target for treatment of cancer due to their roles in …

High macrophage infiltration has been correlated to improved survival in colorectal cancer
(CRC). Tumor associated macrophages (TAMs) play complex roles in tumorigenesis since …

Evading immune destruction and tumor promoting inflammation are important hallmarks in
the development of cancer. Macrophages are present in most human tumors and are often …

Purpose: High-grade osteosarcoma is a malignant primary bone tumor with a peak
incidence in adolescence. Overall survival (OS) of patients with resectable metastatic …

Cancer immunosurveillance relies on effector/memory tumor-infiltrating CD8+ T cells with a
T-helper cell 1 (TH1) profile. Evidence for a natural killer (NK) cell-based control of human …

Imatinib mesylate targets mutated KIT oncoproteins in gastrointestinal stromal tumor (GIST)
and produces a clinical response in 80% of patients. The mechanism is believed to depend …

Mesenchymal gastrointestinal cancers are represented by the gastrointestinal stromal
tumors (GISTs) which occur throughout the whole gastrointestinal tract, and affect human …

Monocytes attracted by tumor-induced chronic inflammation differentiate to APCs, the type of
which depends on cues in the local tumor milieu. In this work, we studied the influence of …