XIAP, X-linked inhibitor of apoptosis protein, is a member of the inhibitor of apoptosis protein
(IAP) family known for its important conserved inhibitory effect on caspase activity. Since the …

Possessing structural homology with their active enzyme counterparts but lacking catalytic
activity, pseudoenzymes have been identified for all major enzyme groups. Caspases are a …

Amyotrophic lateral sclerosis is a neurodegenerative disease in which death of
motoneurons leads to progressive failure of the neuromuscular system resulting in death …

Activation of tumor necrosis factor receptor-1 can trigger survival or apoptosis pathways. In
many cellular models, including the neuronal cell model PC12, it has been demonstrated …

Cellular FLIP (c-FLIP) specifically inhibits caspase-8 and suppresses death receptor–
induced apoptosis. c-FLIP has also been reported to transmit activation signals. In this study …

The neuronal long isoform of Fas Apoptotic Inhibitory Molecule (FAIM-L) protects from death
receptor (DR)-induced apoptosis, yet its mechanism of protection remains unknown. Here …

Caspases have recently emerged as key regulators of axonal pruning and degeneration
and of long-term depression (LTD), a long-lasting form of synaptic plasticity. However, the …

c-Myc is known to induce or potentiate apoptotic processes predominantly by triggering or
enhancing the activity of caspases, but the activation mechanisms of caspases by c-Myc …

Resistance to apoptosis is one of the established hallmarks of cancer cells. This is a function
of an imbalance between the proteins that facilitate death execution and those that inhibit …

X-linked Inhibitor of apoptosis protein (XIAP) has been classically identified as a cell death
regulator. Here, we demonstrate a novel function of XIAP as a regulator of neurite outgrowth …