BACKGROUND Uterine natural killer cells (uNK) are the most abundant lymphocytes found
in the decidua during implantation and in first trimester pregnancy. They are important for …

The comparison of the immunological state of pregnancy to an immunosuppressed host–
graft model continues to lead research and clinical practice to ill-defined approaches. This …

Pregnancy poses an immunological challenge because a genetically distinct (nonself) fetus
must be supported within the pregnant female for the required gestational period …

The metastatic spread of malignant cells to distant anatomical locations is a prominent
cause of cancer-related death. Metastasis is governed by cancer-cell-intrinsic mechanisms …

At implantation, the embryo expresses paternally derived alloantigens and evokes
inflammation that can threaten reproductive success. To ensure a robust placenta and …

Avoiding destruction by immune cells is a hallmark of cancer, yet how tumors ultimately
evade control by natural killer (NK) cells remains incompletely defined. Using global …

During placentation invasive extravillous trophoblasts (EVTs) migrate into the maternal
uterus and modify its vessels. In particular, remodeling of the spiral arteries by EVTs is …

Decidualization denotes the transformation of endometrial stromal fibroblasts into
specialized secretory decidual cells that provide a nutritive and immunoprivileged matrix …

Mononuclear phagocyte plasticity includes the expression of functions related to the
resolution of inflammation, tissue repair and remodelling, particularly when these cells are …

The maternal-fetal interface undergoes dynamic changes to allow the fetus to grow and
develop in the uterus, despite being recognized by the maternal immune cells. Within the …