Synthetic biology is the application of engineering principles to the fundamental components
of biology, with the aim of creating systems with novel functionalities that can be used for …

While noise is generally associated with uncertainties and often has a negative connotation
in engineering, living organisms have evolved to adapt to (and even exploit) such …

Despite recent advances in circuit engineering, the design of genetic networks in
mammalian cells is still painstakingly slow and fraught with inexplicable failures. Here, we …

Growth impacts a range of phenotypic responses. Identifying the sources of growth variation
and their propagation across the cellular machinery can thus unravel mechanisms that …

Genetically engineered photoreceptors enable unrivaled control over gene expression.
Previously, we ported the Synechocystis PCC 6803 CcaSR two‐component system, which is …

Optogenetics is a technology wherein researchers combine light and genetically engineered
photoreceptors to control biological processes with unrivaled precision. Near-infrared (NIR) …

One of the most remarkable features of biological systems is their ability to adapt to the
constantly changing environment. By harnessing principles of control theory, synthetic …

Rapid advances in DNA synthesis, genetic manipulation, and biosensors have greatly
improved the ability to engineer microorganisms with complex functions. By accurately …

Most organisms must cope with temperature changes. This involves genes and gene
networks both as subjects and agents of cellular protection, creating difficulties in …

Population growth is often ignored when quantifying gene expression levels across clonal
cell populations. We develop a framework for obtaining the molecule number distributions in …