Epileptic encephalopathies of infancy and childhood comprise a large, heterogeneous
group of severe epilepsies characterised by several seizure types, frequent epileptiform …

The human gut is colonized by a community of microbiota, primarily bacteria, that exist in a
symbiotic relationship with the host. Intestinal microbiota-host interactions play a critical role …

INTRODUCTION Voltage-gated sodium (Nav) channels are responsible for the generation
and propagation of action potentials in excitable cells. They undergo voltage-dependent …

Voltage-gated sodium channel Na v 1.5 generates cardiac action potentials and initiates the
heartbeat. Here, we report structures of Na V 1.5 at 3.2–3.5 Å resolution. Na V 1.5 is …

Voltage-gated sodium (Na v) channels initiate and propagate action potentials. Here, we
present the cryo-EM structure of EeNa v 1.4, the Na v channel from electric eel, in complex …

The voltage-gated sodium channel Nav1. 2 is responsible for the initiation and propagation
of action potentials in the central nervous system. We report the cryo–electron microscopy …

Voltage-gated sodium channels are essential for the initiation and propagation of the action
potential in neurons and other excitable cells. Because of their critical roles in electrical …

Selective permeation of sodium ions through voltage-dependent sodium channels is
fundamental to the generation of action potentials in excitable cells such as neurons. These …

Venomous animals have evolved a vast array of peptide toxins for prey capture and
defence. These peptides are directed against a wide variety of pharmacological targets …

Pathogenic variants in the voltage-gated sodium channel gene family lead to early onset
epilepsies, neurodevelopmental disorders, skeletal muscle channelopathies, peripheral …