Dendritic spines, the tiny protrusions that stud the surface of many neurons, are the location
of over 90% of all excitatory synapses that occur in the CNS. Their small size has, in large …

Publisher Summary Calmodulin is the major intracellular, and intramembrane, Ca 2+
receptor. Its function is to detect free Ca 2+ and translate changes in Ca 2+ concentrations …

In CNS synapses, the synaptic junctional complex with associated postsynaptic density is
presumed to contain proteins responsible for adhesion between pre-and postsynaptic …

A calcium and calmodulin-dependent protein kinase has been purified from rat brain. It was
monitored during the purification by its ability to phosphorylate the synaptic vesicle …

Twenty-eight years ago, Smithies demonstrated that a starch gel could serve as a molecular
sieve through which zone electrophoresis of proteins could be carried out (95). Since then …

By three criteria, two biochemical and one immunochemical, the major postsynaptic density
protein (mPSDp) is indistinguishable from the 50-kilodalton (kDa) alpha subunit of a brain …

PSD-95/SAP90 is a member of membrane-associated guanylate kinases localized at
postsynaptic density (PSD) in neuronal cells. Membrane-associated guanylate kinases are a …

During synaptic development, proteins aggregate at specialized pre-and postsynaptic
structures. Mechanisms that mediate protein clustering at these sites remain unknown. To …

Synapsin I and calcium/calmodulin-dependent protein kinase II were pressure-injected into
the preterminal digit of the squid giant synapse to test directly the possible regulation of …

Polypeptides of Mr 50,000 and 60,000 in isolated synaptic junctions have been compared to
polypeptides of corresponding molecular weight in Ca2+/calmodulin-dependent protein …