TNF-α gene polymorphisms and expression

RR El-Tahan, AM Ghoneim, N El-Mashad - Springerplus, 2016 - Springer
Tumor necrosis factor alpha (TNF-α) is a proinflammatory cytokine with an important role in
the pathogenesis of several diseases. Its encoding gene is located in the short arm of …

The relationship of ankylosing spondylitis and subclinical atherosclerosis: a systemic review and meta-analysis

R Bai, Y Zhang, W Liu, C Ma, X Chen, J Yang… - Angiology, 2019 - journals.sagepub.com
Cardiovascular disease has become the first cause of death for patients with ankylosing
spondylitis (AS). However, the relevant data is limited and the relationship between AS and …

Genetically determined high activities of the TNF-alpha, IL23/IL17, and NFkB pathways were associated with increased risk of ankylosing spondylitis

J Sode, S Bank, U Vogel, PS Andersen… - BMC Medical …, 2018 - Springer
Background Ankylosing spondylitis (AS) results from the combined effects of susceptibility
genes and environmental factors. Polymorphisms in genes regulating inflammation may …

Tumor necrosis factor alpha-308G/A gene polymorphisms combined with neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio predicts the efficacy and safety of …

Z Wang, L Kong, H Zhang, F Sun, Z Guo… - Frontiers in …, 2022 - frontiersin.org
Background: TNF-α has been reported to be closely associated with autoimmune
inflammatory diseases. This study aims to investigate the role of TNF-α-308 (rs1800629) G/A …

Involvement of tumor necrosis factor alpha in steroid-associated osteonecrosis of the femoral head: friend or foe?

B Fang, D Wang, J Zheng, Q Wei, D Zhan, Y Liu… - Stem cell research & …, 2019 - Springer
Background The etiology and pathology osteonecrosis of the femoral head (ONFH) are not
completely clarified. As a cytokine participating in systemic inflammation, tumor necrosis …

Evaluation of genetic polymorphisms in TNF‑α‑308G/A rs1800629 associated with susceptibility and severity of rheumatoid arthritis: A systematic review and meta …

YL Wang, XY Li, L Liu, SF Li… - Experimental and …, 2024 - spandidos-publications.com
To investigate the association of gene polymorphisms of TNF‑α‑308G/A rs1800629 with the
susceptibility and severity of rheumatoid arthritis (RA), literature from PubMed, EMBASE …

The genetic contribution to drug response in spondyloarthritis: a systematic literature review

A Ortolan, G Cozzi, M Lorenzin, P Galozzi… - Frontiers in …, 2021 - frontiersin.org
Objective: Spondyloarthritis (SpA) are a group of diseases with a high heritability, whose
pathogenesis is strongly determined by an interplay between genetic and environmental …

The association of polymorphisms in TNF and ankylosing spondylitis in common population: a meta-analysis

N Hu, X Chen, S Wang, G Yuan, Q Wang, H Shu… - European Spine …, 2021 - Springer
Background Studies investigating the association between the polymorphisms in TNF and
ankylosing spondylitis have been reported the conflicting results. Here we performed a meta …

Association of TNF-α-308 (G/A) and-238 (G/A) polymorphisms with non-traumatic osteonecrosis of the femoral head risks: a meta-analysis

Y Peng, Y Liu, D Huang, W Huang, Z Shao - International Orthopaedics, 2018 - Springer
Purpose The association between TNF-α-308 (G/A) and-238 (G/A) polymorphisms and the
susceptibility of non-traumatic osteonecrosis of the femoral head (NONFH) was investigated …

Association between cytokine gene polymorphisms and ankylosing spondylitis susceptibility: a systematic review and meta-analysis

Y Xia, Y Liang, S Guo, JG Yu, MS Tang… - Postgraduate …, 2018 - academic.oup.com
Purpose of the study The aim of this study was to perform a meta-analysis to derive precise
estimation of the association of interleukin-23 receptor (IL-23R), IL-1 receptor 2 (IL-1R2), IL …