Since the discovery of Stimulator of Interferon Genes (STING) as an important pivot for
cytosolic DNA sensation and interferon (IFN) induction, intensive efforts have been …

With the continuous development of immunotherapy, researchers have paid more attention
to the specific immune regulatory mechanisms of various immune responses in different …

Antigen identification is an important step in the vaccine development process.
Computational approaches including deep learning systems can play an important role in …

The complexity of host–pathogen interactions often leads to distinct clinical outcomes upon
infection with different pathogen strains. In this Review, we explore the interactions between …

Emerging and re-emerging bacterial infections are a serious threat to human and animal
health. Extracellular bacteria are free-living, while facultative intracellular bacteria replicate …

Mutations in the TREX1 3'→ 5'exonuclease are associated with a spectrum of autoimmune
disease phenotypes in humans and mice. Failure to degrade DNA activates the cGAS …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Chagas disease is currently endemic to 21 Latin-American countries and has also become a
global concern because of globalization and mass migration of chronically infected …

The SARS-CoV-2 pandemic has almost 56 million confirmed cases resulting in over 1.3
million deaths as of November 2020. This infection has proved more deadly to older adults …

Chagas disease (ChD), caused by the hemoflagellate parasite Trypanosoma cruzi, affects
six to seven million people in Latin America. Lately, it has become an emerging public …