Membrane lipids in presynaptic function and disease
E Lauwers, R Goodchild, P Verstreken - Neuron, 2016 - cell.com
Lipids are the most abundant organic compounds in the brain. The brain has a unique
lipidome, and changes in lipid concentration, organization, and metabolism are associated …
lipidome, and changes in lipid concentration, organization, and metabolism are associated …
α-Synuclein in Parkinson's disease: causal or bystander?
Parkinson's disease (PD) comprises a spectrum of disorders with differing subtypes, the vast
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …
The vermiform appendix impacts the risk of developing Parkinson's disease
The pathogenesis of Parkinson's disease (PD) involves the accumulation of aggregated α-
synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we …
synuclein, which has been suggested to begin in the gastrointestinal tract. Here, we …
Dynamic physiological α-synuclein S129 phosphorylation is driven by neuronal activity
In Parkinson's disease and other synucleinopathies, the elevation of α-synuclein
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
phosphorylated at Serine129 (pS129) is a widely cited marker of pathology. However, the …
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
CPA Doherty, SM Ulamec, R Maya-Martinez… - Nature structural & …, 2020 - nature.com
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
C Zhang, Y Pei, Z Zhang, L Xu, X Liu, L Jiang… - Communications …, 2022 - nature.com
Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
The novel Parkinson's disease linked mutation G51D attenuates in vitro aggregation and membrane binding of α-synuclein, and enhances its secretion and nuclear …
A novel mutation in the α-Synuclein (α-Syn) gene “G51D” was recently identified in two
familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy …
familial cases exhibiting features of Parkinson's disease (PD) and multiple system atrophy …
Fibrillar α-synuclein and huntingtin exon 1 assemblies are toxic to the cells
L Pieri, K Madiona, L Bousset, R Melki - Biophysical journal, 2012 - cell.com
The aggregation of alpha-synuclein (α-syn) and huntingtin (htt) into fibrillar assemblies in
nerve and glial cells is a molecular hallmark of Parkinson's and Huntington's diseases …
nerve and glial cells is a molecular hallmark of Parkinson's and Huntington's diseases …
The bacterial curli system possesses a potent and selective inhibitor of amyloid formation
Curli are extracellular functional amyloids that are assembled by enteric bacteria during
biofilm formation and host colonization. An efficient secretion system and chaperone …
biofilm formation and host colonization. An efficient secretion system and chaperone …
Postsynaptic synucleins mediate endocannabinoid signaling
Endocannabinoids are among the most powerful modulators of synaptic transmission
throughout the nervous system, and yet little is understood about the release of …
throughout the nervous system, and yet little is understood about the release of …