CK2 is a constitutively active Ser/Thr protein kinase, which phosphorylates hundreds of
substrates, controls several signaling pathways, and is implicated in a plethora of human …

Like the organism they constitute, the cells also die in different ways. The death can be
predetermined, programmed, and cleanly executed, as in the case of apoptosis, or it can be …

Macropinocytosis is an important mechanism of internalizing extracellular materials and
dissolved molecules in eukaryotic cells. Macropinocytosis has a dual effect on cancer cells …

Background Protein kinase CK2 inhibition has long been considered as an attractive anti-
cancer strategy based on the following considerations: CK2 is a pro-survival kinase, it is …

The fate of a viral infection in the host begins with various types of cellular responses, such
as abortive, productive, latent, and destructive infections. Apoptosis, necroptosis, and …

Macropinocytosis is a widely-observed and evolutionarily-conserved endocytic process
found in the eukaryotic cells. In comparison to other endocytic routes, macropinocytosis …

Naphthyridine-based inhibitors were synthesized to yield a potent and cell-active inhibitor of
casein kinase 2 (CK2). Compound 2 selectively inhibits CK2α and CK2α′ when profiled …

CK2 is a constitutively active Ser/Thr protein kinase which phosphorylates hundreds of
substrates. Since they are primarily related to survival and proliferation pathways, the best …

Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase
signalling. Since inhibitor-resistant kinase mutants (ie, drug-resistant alleles) remain active …

Drug-resistant parasitic nematodes pose a grave threat to plants, animals, and humans. An
innovative paradigm for treating parasitic nematodes is emphasized in this opinion. This …