Aggregation and phase separation of α-synuclein in Parkinson's disease

W Han, M Wei, F Xu, Z Niu - Chemical Communications, 2024 - pubs.rsc.org
The deposition of α-synuclein (α-Syn) in Lewy bodies serves as a prominent pathological
hallmark of Parkinson's disease (PD). Recent research has revealed that α-Syn can undergo …

Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization

M Zhu, H Xu, Y Jin, X Kong, B Xu, Y Liu, H Yu - Journal of Cell Biology, 2024 - rupress.org
Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in
synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the …

HcCnAα regulates NF-κB signaling in Hyriopsis cumingii by interacting with HcIKK and facilitating IκB phosphorylation

Y Li, Q Yang, G He, K Long, X Tang, Y Su… - International Journal of …, 2025 - Elsevier
Abstract Calcineurin (CN), a serine/threonine protein phosphatase regulated by Ca 2+ and
calmodulin, plays a crucial role in the immune response of bivalves. In this study, we …