Diabetes, metabolic disease, and telomere length

F Cheng, L Carroll, MV Joglekar… - The Lancet Diabetes & …, 2021 - thelancet.com
Telomeres are regions of repetitive nucleotide sequences at the ends of chromosomes.
Telomere length is a marker of DNA damage, which is often considered a biomarker for …

[HTML][HTML] Telomere length and all-cause mortality: a meta-analysis

Q Wang, Y Zhan, NL Pedersen, F Fang, S Hägg - Ageing research reviews, 2018 - Elsevier
Telomere attrition is associated with increased morbidity and mortality of various age-related
diseases. Reports of association between telomere length (TL) and all-cause mortality …

[HTML][HTML] Biomarkers in diabetic retinopathy

AJ Jenkins, MV Joglekar, AA Hardikar… - The review of diabetic …, 2015 - ncbi.nlm.nih.gov
There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …

Peripheral blood leukocyte telomere length and mortality among 64 637 individuals from the general population

L Rode, BG Nordestgaard… - Journal of the National …, 2015 - academic.oup.com
Background: Short telomeres in peripheral blood leukocytes are associated with older age
and age-related diseases. We tested the hypotheses that short telomeres are associated …

Childhood adversity heightens the impact of later-life caregiving stress on telomere length and inflammation

JK Kiecolt-Glaser, JP Gouin, N Weng… - Psychosomatic …, 2011 - journals.lww.com
Objective: To address the question of whether childhood abuse and other adversities have
lasting, detectable consequences for inflammation and cell aging late in life, and whether …

Telomere length measurement as a clinical biomarker of aging and disease

CL Fasching - Critical reviews in clinical laboratory sciences, 2018 - Taylor & Francis
Telomere length measurement is increasingly recognized as a clinical gauge for age-related
disease risk. There are several methods for studying blood telomere length (BTL) as a …

Leukocyte telomere length and mortality in the Cardiovascular Health Study

AL Fitzpatrick, RA Kronmal, M Kimura… - … Series A: Biomedical …, 2011 - academic.oup.com
Background. Leukocyte telomere length (LTL) is related to diseases of aging, but studies of
mortality have been inconsistent. Methods. We evaluated LTL in relation to total mortality …

Genetic susceptibility to chronic kidney disease–some more pieces for the heritability puzzle

M Cañadas-Garre, K Anderson, R Cappa… - Frontiers in …, 2019 - frontiersin.org
Chronic kidney disease (CKD) is a major global health problem with an increasing
prevalence partly driven by aging population structure. Both genomic and environmental …

Leukocyte telomere length and mortality in the National Health and Nutrition Examination Survey, 1999–2002

BL Needham, D Rehkopf, N Adler, S Gregorich… - …, 2015 - journals.lww.com
Background: This study examined the association between leukocyte telomere length—a
marker of cell aging—and mortality in a nationally representative sample of US adults ages …

The telomere/telomerase system in chronic inflammatory diseases. Cause or effect?

V Kordinas, A Ioannidis, S Chatzipanagiotou - Genes, 2016 - mdpi.com
Telomeres are specialized nucleoprotein structures located at the end of linear
chromosomes and telomerase is the enzyme responsible for telomere elongation …