In the last two decades, solid-state nuclear magnetic resonance (ssNMR) spectroscopy has
transformed from a spectroscopic technique investigating small molecules and industrial …

The Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB),
funded by the United States National Science Foundation, National Institutes of Health, and …

Membrane proteins perform a host of vital cellular functions. Deciphering the molecular
mechanisms whereby they fulfill these functions requires detailed biophysical and structural …

A third of the genes in prokaryotic and eukaryotic genomes encode membrane proteins that
are either essential for signal transduction and solute transport or function as scaffold …

Abstract α-Helical coiled coils are ubiquitous protein-folding and protein-interaction domains
in which two or more α-helical chains come together to form bundles. Through a …

Protein secondary and tertiary structure mimics have served as model systems to probe
biophysical parameters that guide protein folding and as attractive reagents to modulate …

Conspectus Membrane proteins mediate a plethora of cellular functions and represent
important targets for drug development. Unlike soluble proteins, membrane proteins require …

Cardiovascular disease (CVD) is one of the leading causes of death and disability, and has
always been a hotspot in clinical and scientific research. The illness brings a heavy …

The capability to handle highly heterogeneous molecular assemblies in a consistent manner
is among the greatest challenges faced when deriving simulation parameters. This is …

Phospholamban (PLN) is a mini-membrane protein that directly controls the cardiac Ca2+-
transport response to β-adrenergic stimulation, thus modulating cardiac output during the …