The DYRK family of kinases in cancer: molecular functions and therapeutic opportunities
DYRK (dual-specificity tyrosine-regulated kinases) are an evolutionary conserved family of
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
protein kinases with members from yeast to humans. In humans, DYRKs are pleiotropic …
Emerging roles of DYRK2 in cancer
Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
across various cancers triggering major antitumor and proapoptotic signals in breast, colon …
Discovery of nanomolar DCAF1 small molecule ligands
ASM Li, S Kimani, B Wilson, M Noureldin… - Journal of Medicinal …, 2023 - ACS Publications
DCAF1 is a substrate receptor of two distinct E3 ligases (CRL4DCAF1 and EDVP), plays a
critical physiological role in protein degradation, and is considered a drug target for various …
critical physiological role in protein degradation, and is considered a drug target for various …
PAF and EZH2 induce Wnt/β-catenin signaling hyperactivation
HY Jung, S Jun, M Lee, HC Kim, X Wang, H Ji… - Molecular cell, 2013 - cell.com
Fine control of Wnt signaling is essential for various cellular and developmental decision-
making processes. However, deregulation of Wnt signaling leads to pathological …
making processes. However, deregulation of Wnt signaling leads to pathological …
Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT
L Xi, TR Cech - Nucleic acids research, 2014 - academic.oup.com
Telomerase is the ribonucleoprotein (RNP) enzyme that elongates telomeric DNA to
compensate for the attrition occurring during each cycle of DNA replication. Knowing the …
compensate for the attrition occurring during each cycle of DNA replication. Knowing the …
LIG4 mediates Wnt signalling-induced radioresistance
Despite the implication of Wnt signalling in radioresistance, the underlying mechanisms are
unknown. Here we find that high Wnt signalling is associated with radioresistance in …
unknown. Here we find that high Wnt signalling is associated with radioresistance in …
The regulations of telomerase reverse transcriptase (TERT) in cancer
M Liu, Y Zhang, Y Jian, L Gu, D Zhang, H Zhou… - Cell Death & …, 2024 - nature.com
Abnormal activation of telomerase occurs in most cancer types, which facilitates escaping
from cell senescence. As the key component of telomerase, telomerase reverse …
from cell senescence. As the key component of telomerase, telomerase reverse …
A novel CDC25A/DYRK2 regulatory switch modulates cell cycle and survival
M Lara-Chica, A Correa-Sáez… - Cell Death & …, 2022 - nature.com
The cell division cycle 25A (CDC25A) phosphatase is a key regulator of cell cycle
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …
progression that acts on the phosphorylation status of Cyclin–Cyclin-dependent kinase …
Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin
Evasion of apoptosis allows many cancers to resist chemotherapy. Apoptosis is mediated by
the serial activation of caspase family proteins. These proteases are often activated upon the …
the serial activation of caspase family proteins. These proteases are often activated upon the …
[HTML][HTML] Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Wnt2 is implicated in various human cancers. However, it remains unknown how Wnt2 is
upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is …
upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is …