Formal [4+ 1] annulation reactions in the synthesis of carbocyclic and heterocyclic systems

JR Chen, XQ Hu, LQ Lu, WJ Xiao - Chemical reviews, 2015 - ACS Publications
The development of new strategies and chemical reactions continues to be a major focus of
research efforts in the modern synthetic organic community. 1 Of the various types of …

Benefits of unconventional methods in the total synthesis of natural products

T Hudlicky - ACS omega, 2018 - ACS Publications
This article provides a survey of four “unconventional” methods employed in the synthesis of
natural products in the Hudlicky group. The utility of flash vacuum pyrolysis is highlighted by …

Toluene Dioxygenase-Mediated cis-Dihydroxylation of Aromatics in Enantioselective Synthesis. Asymmetric Total Syntheses of Pancratistatin and 7-Deoxypancratistatin …

T Hudlicky, X Tian, K Königsberger… - Journal of the …, 1996 - ACS Publications
Whole-cell biooxidation of bromobenzene with Pseudomonas putida 39D or the
recombinant Escherichia coli JM109 (pDTG601) yields (1 S, 2 S)-3-bromocyclohexa-3, 5 …

Celebrating 20 years of Synlett-Special account on the merits of biocatalysis and the impact of arene cis-dihydrodiols on enantioselective synthesis

T Hudlicky, JW Reed - Synlett, 2009 - thieme-connect.com
This account is a tribute to Professor David Gibson in recognition of his discovery of
enzymatic dihydroxylation of aromatic compounds four decades ago. Here are highlighted …

Symmetry‐based design for the chemoenzymatic synthesis of oseltamivir (Tamiflu) from ethyl benzoate

B Sullivan, I Carrera, M Drouin… - Angewandte Chemie, 2009 - Wiley Online Library
The possibility of a major influenza pandemic (especially the avian H5N1 influenza)
continues to be a serious health concern. The development of effective antiviral medicines is …

Pyrrolizidine and indolizidine syntheses involving 1, 3-Dipolar cycloadditions

G Broggini, G Zecchi - Synthesis, 1999 - thieme-connect.com
Pyrrolizidine and Indolizidine Syntheses Involving 1,3-Dipolar Cycloadditions Page 1 REVIEW
905 Synthesis 1999, No. 6, 905–917 ISSN 0039-7881 © Thieme Stuttgart · New York …

A Direct Route to C-Vinylaziridines:  Reaction of N-Sufonylimines with Allylic Ylides under Phase-Transfer Conditions or with Preformed Ylides at Low Temperature

AH Li, LX Dai, XL Hou, MB Chen - The Journal of Organic …, 1996 - ACS Publications
Allylic sulfonium salts 3, 5, 7, 11, 12, 13, and arsonium salt 14 react with aromatic,
heteroaromatic, and α, β-unsaturated N-sulfonylimines under solid− liquid phase-transfer …

Total syntheses of (+)-australine and (−)-7-epialexine

WH Pearson, JV Hines - The Journal of organic chemistry, 2000 - ACS Publications
Three approaches were examined for the synthesis of 3-(hydroxymethyl) pyrrolizidines, a
class of compounds that includes the polyhydroxylated pyrrolizidine alkaloids alexine (1) …

Aza‐[3, 3]‐claisen enolate rearrangement in vinylaziridines: Stereoselective synthesis of mono‐, di‐, and trisubstituted seven‐membered lactams

UM Lindström, P Somfai - Chemistry–A European Journal, 2001 - Wiley Online Library
Abstract Several 2, 3‐disubstituted vinylaziridines have been N‐acylated and subjected to
LiHMDS in THF at− 78° C. Upon warming to room temperature, the resulting amide enolates …

Titanium-Mediated cyclization of ω-vinyl imides in alkaloid synthesis: isoretronecanol, trachelanthamidine, 5-epitashiromine, and tashiromine

SH Kim, SI Kim, S Lai, JK Cha - The Journal of Organic Chemistry, 1999 - ACS Publications
A new method for the stereocontrolled synthesis of pyrrolizidine and indolizidine alkaloids
by means of titanium-mediated cyclization of ω-vinyl imides is described. The general …