[HTML][HTML] Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
E Ten Hacken, JA Burger - Biochimica et Biophysica Acta (BBA)-Molecular …, 2016 - Elsevier
Abstract Chronic Lymphocytic Leukemia (CLL) is a malignancy of mature B lymphocytes
which are highly dependent on interactions with the tissue microenvironment for their …
which are highly dependent on interactions with the tissue microenvironment for their …
The microenvironment in mature B-cell malignancies: a target for new treatment strategies
Despite major therapeutic advances, most mature B-cell malignancies remain incurable.
Compelling evidence suggests that crosstalk with accessory stromal cells in specialized …
Compelling evidence suggests that crosstalk with accessory stromal cells in specialized …
Survivin is expressed on CD40 stimulation and interfaces proliferation and apoptosis in B-cell chronic lymphocytic leukemia
L Granziero, P Ghia, P Circosta… - Blood, The Journal …, 2001 - ashpublications.org
In B-cell chronic lymphocytic leukemia (B-CLL), defective apoptosis causes the
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …
accumulation of mature CD5+ B cells in lymphoid organs, bone marrow (BM), and …
The role of CD44 in cancer chemoresistance: A concise review
CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells.
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …
Nurture versus nature: the microenvironment in chronic lymphocytic leukemia
JA Burger - Hematology 2010, the American Society of …, 2011 - ashpublications.org
Intrinsic factors such as genetic lesions, anti-apoptotic proteins, and aberrant signaling
networks within leukemia cells have long been the main focus of chronic lymphocytic …
networks within leukemia cells have long been the main focus of chronic lymphocytic …
Chronic lymphocytic leukemia: revelations from the B-cell receptor
FK Stevenson, F Caligaris-Cappio - Blood, 2004 - ashpublications.org
The finding that chronic lymphocytic leukemia (CLL) consists of 2 clinical subsets,
distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable …
distinguished by the incidence of somatic mutations in the immunoglobulin (Ig) variable …
The Akt/Mcl-1 pathway plays a prominent role in mediating antiapoptotic signals downstream of the B-cell receptor in chronic lymphocytic leukemia B cells
Sustained engagement of the B-cell receptor (BCR) increases apoptosis resistance in
chronic lymphocytic leukemia (CLL) B cells, whereas transient stimulation usually has an …
chronic lymphocytic leukemia (CLL) B cells, whereas transient stimulation usually has an …
The mechanism of tumor cell clearance by rituximab in vivo in patients with B-cell chronic lymphocytic leukemia: evidence of caspase activation and apoptosis …
Rituximab is a chimeric monoclonal antibody directed at CD20 with significant activity in non-
Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of …
Hodgkin lymphoma (NHL) and chronic lymphocytic leukemia (CLL). A variety of pathways of …
Constitutively activated phosphatidylinositol-3 kinase (PI-3K) is involved in the defect of apoptosis in B-CLL: association with protein kinase Cδ
I Ringshausen, F Schneller, C Bogner… - Blood, The Journal …, 2002 - ashpublications.org
In the present study we analyzed the role of phophatidylinositol-3 kinase (PI-3K) in B chronic
lymphocytic leukemia (B-CLL) cells. PI-3K is activated by many stimuli and is linked to …
lymphocytic leukemia (B-CLL) cells. PI-3K is activated by many stimuli and is linked to …
Inhibition of constitutive and BCR-induced Syk activation downregulates Mcl-1 and induces apoptosis in chronic lymphocytic leukemia B cells
S Gobessi, L Laurenti, PG Longo, L Carsetti, V Berno… - Leukemia, 2009 - nature.com
The protein kinase Syk is a key mediator of proximal B-cell receptor (BCR) signaling.
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …
Following antigen stimulation, Syk is recruited to the BCR and becomes activated by …