The tryptophan (TRP)-kynurenine (KYN) metabolic pathway is a main player of TRP
metabolism through which more than 95% of TRP is catabolized. The pathway is activated …

Aging is characterized by a progressive decline in the normal physiological functions of an
organism, ultimately leading to mortality. Nicotinamide adenine dinucleotide (NAD+) is an …

In recent decades, neuropsychiatric disorders such as major depressive disorder,
schizophrenia, bipolar, etc., have become a global health concern, causing various …

The high morbidity and mortality of neuroinflammatory diseases drives significant interest in
understanding the underlying mechanisms involved in the innate and adaptive immune …

Over the past years, an increasing amount of evidence has emerged in support of the
kynurenine pathway's (KP) pivotal role in the pathogenesis of several neurodegenerative …

Background: Cellular metabolism is critical for the host immune function against pathogens,
and metabolomic analysis may help understand the characteristic immunopathology of …

Abstract Purpose of Review Early identification of infection in the critically ill patient and
initiation of appropriate treatment is key to reducing morbidity and mortality. On the other …

Background Metabolomics is the study of small molecules to simultaneously identify multiple
low molecular weight molecules in a system. Broadly speaking, metabolomics can be …

Amyotrophic Lateral Sclerosis (ALS) currently lacks a robust and well-defined biomarker that
can 1) assess the progression of the disease, 2) predict and/or delineate the various clinical …

Amino acids and their metabolites are key regulators of immune responses, and plasma
levels may change profoundly during acute disease states. Using targeted metabolomics …