The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …

Privileged scaffolds as starting points toward biologically active molecules represent a
neuralgic point in drug discovery. The ability of synthetic chemists concerned with their …

1, 3, 4-Oxadiazole, a five-membered aromatic ring can be seen in a number of synthetic
molecules. The peculiar structural feature of 1, 3, 4-oxadiazole ring with pyridine type of …

Epilepsy is one of the most important neurological disorders with high prevalence
worldwide. Many epileptic patients are not completely treated with available drugs and need …

Epilepsy is the most common neurological disorder, which affects more than 50 million
people worldwide. Despite the development and use of several antiepileptic drugs (AEDs) …

A new series of pyrrole‐linked mono‐and bis (1, 3, 4‐oxadiazole) hybrids, attached to
various arene units, was prepared using a two‐step tandem protocol. Therefore, a …

Oxadiazoles are five-membered heterocyclic molecules possessing two carbon, two
nitrogen, and one oxygen atom. They exist in four regioisomeric forms and established their …

Abstract A new series of 5-(2-aryloxy-4-nitrophenyl)-4H-1, 2, 4-triazoles and 5-(2-aryloxy-3-
pyridyl)-4H-1, 2, 4-triazoles, possessing C-3 thio or alkylthio substituents, was synthesized …

The traditional approach of the drug discovery process involves the designing of ligands
with maximum selectivity for a particular target leading to a prolonged effect. Therefore, a …

The signal transmission in the nervous system operates through a sensitive balance
between excitatory (E) inputs and inhibitory (I) responses. Imbalances in this system …